Fedewa Michael V, Bentley Jessica L, Higgins Simon, Kindler Joseph M, Esco Michael R, MacDonald Hayley V
Department of Kinesiology, The University of Alabama, Tuscaloosa, AL, USA.
Department of Kinesiology, The University of Alabama, Tuscaloosa, AL, USA.
J Clin Densitom. 2020 Apr-Jun;23(2):200-211. doi: 10.1016/j.jocd.2019.02.003. Epub 2019 Feb 13.
Celiac disease is characterized by deficits in bone mineral accrual and longitudinal growth.
The purpose of this study was to determine the differences in bone health and stature among children and adolescents with celiac disease versus healthy controls.
Articles published before February 27, 2018 were located using searches of the Physical Education Index (n = 186), PubMed (n = 180), Scopus (n = 3), SPORTDiscus (n = 3), and Web of Science (n = 4).
Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed via dual-energy X-ray absorptiometry, and height was measured using a stadiometer.
Effect sizes (ES) were calculated as follows: the mean difference of the celiac disease group and healthy control group, divided by the pooled standard deviation. The inverse variance weight was used to calculate the overall mean ES. Random-effects models were used to aggregate a mean ES, 95% confidence intervals (CIs) and to identify potential moderators.
The results of 30 effects gathered from 12 studies published between 1996 and 2017 indicated BMC (ES = -0.54, 95% CI: -0.69 to -0.40; p < 0.0001) and aBMD (ES = 0.72, 95% CI: -0.96 to -0.47; p < 0.0001) were lower in youth with celiac disease.
These results were limited to only cross-sectional and baseline data from longitudinal studies reporting BMC and BMD, however did not assess changes in bone health over time.
Children and adolescents with celiac disease have suboptimal bone health and shorter stature.
乳糜泻的特征是骨矿物质积累和纵向生长不足。
本研究的目的是确定乳糜泻儿童和青少年与健康对照者在骨骼健康和身高方面的差异。
通过检索体育教育索引（n = 186）、PubMed（n = 180）、Scopus（n = 3）、SPORTDiscus（n = 3）和科学网（n = 4），查找2018年2月27日前发表的文章。
通过双能X线吸收法评估骨矿物质含量（BMC）和骨面积密度（aBMD），使用身高计测量身高。
效应量（ES）计算如下：乳糜泻组与健康对照组的平均差异除以合并标准差。采用逆方差权重计算总体平均ES。使用随机效应模型汇总平均ES、95%置信区间（CI）并识别潜在的调节因素。
从1996年至2017年发表的12项研究中收集的30个效应结果表明，乳糜泻青少年的BMC（ES = -0.54，95%CI：-0.69至-0.40；p < 0.0001）和aBMD（ES = 0.72，95%CI：-0.96至-0.47；p < 0.0001）较低。
这些结果仅限于报告BMC和BMD的纵向研究的横断面和基线数据，未评估骨骼健康随时间的变化。
患有乳糜泻的儿童和青少年骨骼健康欠佳且身材较矮。
