Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Eur J Intern Med. 2019 May;63:62-68. doi: 10.1016/j.ejim.2019.02.017. Epub 2019 Mar 2.
Takotsubo syndrome is an acute heart failure syndrome often preceded by a trigger factor of physical or emotional origin, although the proportion is unclear. The aim of the present study was to determine how common different trigger factors are in takotsubo syndrome divided by sex and age in women.
The study consisted of a systematic review of all available case reports in PubMed and Web of Science up to March 2018. Trigger factors were categorized into physical and emotional trigger factors.
Males had to a higher degree experienced a trigger factor (92.6%) compared to females (81.9%, p < .001). Physical trigger factors were most common (67.3%). Males had to a higher degree experienced a physical trigger factor (85.7%) compared to females (63.5%, p < .001). Females ≤50 years of age had to a higher degree experienced a trigger factor (90.8%) compared to females >50 years of age (79.2%, p < .001). Additionally, females ≤50 years of age had to a higher degree experienced a physical trigger factor (75.6%) compared to females >50 years of age (59.3%, p < .01).
A physical trigger factor is more common than an emotional trigger factor in takotsubo syndrome. Physical triggers includes drugs, surgery and central nervous system conditions. Furthermore, females ≤50 years of age and males more often have an evident trigger factor and it is more often physical, compared to the most common patient, a female >50 years of age.
Takotsubo 综合征是一种急性心力衰竭综合征，常以前驱因素为物理或情绪来源，尽管其比例尚不清楚。本研究的目的是确定在女性 Takotsubo 综合征中按性别和年龄划分的不同触发因素的常见程度。
本研究包括对截至 2018 年 3 月在 PubMed 和 Web of Science 中所有可用病例报告的系统评价。触发因素分为身体和情绪触发因素。
男性比女性（92.6%对 81.9%，p<0.001）更有可能经历触发因素。身体触发因素最常见（67.3%）。男性比女性（85.7%对 63.5%，p<0.001）更有可能经历身体触发因素。≤50 岁的女性比>50 岁的女性（90.8%对 79.2%，p<0.001）更有可能经历触发因素。此外，≤50 岁的女性比>50 岁的女性（75.6%对 59.3%，p<0.01）更有可能经历身体触发因素。
Takotsubo 综合征中，身体触发因素比情绪触发因素更常见。身体触发因素包括药物、手术和中枢神经系统疾病。此外，≤50 岁的女性和男性比最常见的患者（>50 岁的女性）更常出现明显的触发因素，而且更常是身体触发因素。
