Amato M, de Roche B, von Muralt G
Padiatr Padol. 1986;21(1):25-30.
Persistent pulmonary hypertension of the newborn (PPHN) is a cyanotic syndrome that occurs primarily in full-term and postmature infants and causes right-to-left shunts at the atrial or ductal levels or both. Term babies with PPHN show structural changes in pulmonary vascular smooth muscle as a result of chronic prenatal distress. It is our opinion that in preterm babies the PPHN syndrome also exists. In this group of patients the potential pathways to the persistence of high pulmonary vascular resistence are only functional vascular changes precipitated by acute perinatal stress. The cyanosis of PPHN is rapidly regredient in preterm infants and clinical resolution occurs promptly if the diagnosis is correct and the treatment is started as early as possible in centers capable of extensive monitoring and neonatal supportive care to minimize the risks of Tolazoline therapy.
新生儿持续性肺动脉高压（PPHN）是一种主要发生于足月儿和过期产儿的青紫综合征，可导致心房或导管水平或两者均出现右向左分流。患有PPHN的足月儿由于慢性产前窘迫，其肺血管平滑肌会出现结构变化。我们认为，早产儿中也存在PPHN综合征。在这组患者中，肺血管阻力持续升高的潜在途径仅是由急性围产期应激引发的功能性血管变化。PPHN导致的青紫在早产儿中会迅速消退，如果诊断正确且在具备广泛监测和新生儿支持治疗能力的中心尽早开始治疗，以尽量降低妥拉唑啉治疗风险，临床症状会迅速缓解。
