Immunology of stroke: from animal models to clinical trials.
作者信息
Schmidt-Pogoda Antje, Minnerup Jens, Kleinschnitz Christoph
机构信息
Department of Neurology, Münster University Hospital, Münster, Germany.
Essen University Hospital, Department of Neurology, Hufelandstraße 55, 45147 Essen, Germany.
出版信息
Ther Adv Neurol Disord. 2019 Feb 21;12:1756286419830862. doi: 10.1177/1756286419830862. eCollection 2019.
Abstract
摘要
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Ther Adv Neurol Disord. 2019 Feb 21;12:1756286419830862. doi: 10.1177/1756286419830862. eCollection 2019.
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The choroid plexus is a key cerebral invasion route for T cells after stroke.脉络丛是中风后 T 细胞进入大脑的关键途径。
Acta Neuropathol. 2017 Dec;134(6):851-868. doi: 10.1007/s00401-017-1758-y. Epub 2017 Jul 31.
2
Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial.那他珠单抗治疗急性缺血性脑卒中患者的安全性和有效性（ACTION）：一项随机、安慰剂对照、双盲 2 期试验。
Lancet Neurol. 2017 Mar;16(3):217-226. doi: 10.1016/S1474-4422(16)30357-X. Epub 2017 Feb 15.
3
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.共生微生物群通过调节肠道γδ T细胞影响缺血性中风的预后。
Nat Med. 2016 May;22(5):516-23. doi: 10.1038/nm.4068. Epub 2016 Mar 28.
4
Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic Stroke: A Pilot Trial.免疫调节剂芬戈莫德与阿替普酶联合用于急性缺血性卒中：一项试点试验。
Circulation. 2015 Sep 22;132(12):1104-1112. doi: 10.1161/CIRCULATIONAHA.115.016371. Epub 2015 Jul 22.
5
Impact of an immune modulator fingolimod on acute ischemic stroke.免疫调节剂芬戈莫德对急性缺血性卒中的影响。
Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18315-20. doi: 10.1073/pnas.1416166111. Epub 2014 Dec 8.
6
Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.调节性 T 细胞通过诱导脑微血管功能障碍，强烈促进小鼠的急性缺血性脑卒中。
Blood. 2013 Jan 24;121(4):679-91. doi: 10.1182/blood-2012-04-426734. Epub 2012 Nov 15.
7
Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.抑制淋巴细胞迁移可防止中风后大脑受到有害的神经炎症的侵害。
Brain. 2011 Mar;134(Pt 3):704-20. doi: 10.1093/brain/awr008.
8
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation.实验性脑缺血早期的 T 细胞损伤效应既与适应性免疫无关，也与血栓形成无关。
Blood. 2010 May 6;115(18):3835-42. doi: 10.1182/blood-2009-10-249078. Epub 2010 Mar 9.
9
Temporal and spatial dynamics of cerebral immune cell accumulation in stroke.中风时脑内免疫细胞积聚的时空动态变化
Stroke. 2009 May;40(5):1849-57. doi: 10.1161/STROKEAHA.108.534503. Epub 2009 Mar 5.
10
Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial.抗细胞间黏附分子-1疗法在缺血性卒中中的应用：恩利单抗急性卒中试验结果
Neurology. 2001 Oct 23;57(8):1428-34. doi: 10.1212/wnl.57.8.1428.
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