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Beneficial effects of sacubitril/valsartan in heart failure with reduced ejection fraction: pas à cause du BNP?

作者信息

Pereira Naveen L, Desai Viral K, Jaffe Allan S

机构信息

Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.

Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

出版信息

Eur J Heart Fail. 2019 May;21(5):609-612. doi: 10.1002/ejhf.1451. Epub 2019 Mar 4.

DOI:10.1002/ejhf.1451
PMID:30834697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6508995/
Abstract
摘要

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Initiation of Angiotensin-Neprilysin Inhibition After Acute Decompensated Heart Failure: Secondary Analysis of the Open-label Extension of the PIONEER-HF Trial.急性失代偿性心力衰竭后血管紧张素-脑啡肽酶抑制剂的启动：PIONEER-HF 试验开放标签扩展的二次分析。
JAMA Cardiol. 2020 Feb 1;5(2):202-207. doi: 10.1001/jamacardio.2019.4665.
2
Effects of sacubitril/valsartan on neprilysin targets and the metabolism of natriuretic peptides in chronic heart failure: a mechanistic clinical study.沙库巴曲缬沙坦对慢性心力衰竭脑啡肽酶靶点及利钠肽代谢的影响：一项机制性临床研究。
Eur J Heart Fail. 2019 May;21(5):598-605. doi: 10.1002/ejhf.1342. Epub 2018 Dec 6.
3
Rationale and methods of the Prospective Study of Biomarkers, Symptom Improvement, and Ventricular Remodeling During Sacubitril/Valsartan Therapy for Heart Failure (PROVE-HF).
前瞻性研究生物标志物、症状改善和沙库巴曲缬沙坦治疗心力衰竭期间心室重构的原理和方法（PROVE-HF）。
Am Heart J. 2018 May;199:130-136. doi: 10.1016/j.ahj.2017.12.021. Epub 2018 Feb 13.
4
Natriuretic Peptides and Analytical Barriers.利钠肽与分析障碍
Clin Chem. 2017 Jan;63(1):50-58. doi: 10.1373/clinchem.2016.254714. Epub 2016 Oct 10.
5
Prognostic Implications of Changes in N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Heart Failure.心力衰竭患者 N 端脑利钠肽前体水平变化的预后意义。
J Am Coll Cardiol. 2016 Dec 6;68(22):2425-2436. doi: 10.1016/j.jacc.2016.09.931.
6
A Test in Context: Neprilysin: Function, Inhibition, and Biomarker.在背景下的检验：脑啡肽酶：功能、抑制和生物标志物。
J Am Coll Cardiol. 2016 Aug 9;68(6):639-653. doi: 10.1016/j.jacc.2016.04.060.
7
Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction.沙库巴曲缬沙坦（LCZ696）在射血分数降低的心力衰竭患者中的药效学和药代动力学特征
Cardiovasc Ther. 2016 Aug;34(4):191-8. doi: 10.1111/1755-5922.12183.
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Different Susceptibility of B-Type Natriuretic Peptide (BNP) and BNP Precursor (proBNP) to Cleavage by Neprilysin: The N-Terminal Part Does Matter.B型利钠肽（BNP）和BNP前体（proBNP）对中性内肽酶切割的不同敏感性：N端部分至关重要。
Clin Chem. 2016 Apr;62(4):617-22. doi: 10.1373/clinchem.2016.254524. Epub 2016 Feb 10.
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