International Institute of Pharmaceutical Sciences, Sonepat, Haryana, India.
Laboratory of Preservation Technology and Enzyme Inhibition Studies, Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
Curr Top Med Chem. 2019;19(2):116-122. doi: 10.2174/1568026619666190301173958.
Several phenolic compounds bind to proteins (such as enzymes) and interfere in their catalytic mechanism. Interaction studies of natural polyphenol; Resveratrol with various targets like with tubulin, protein kinase C alpha (PKCα), phosphodiesterase-4D, human oral cancer cell line proteins, DNA sequences having AATT/TTAA segments, protein kinase C alpha, lysine-specific demethylase 1 have been reviewed in this article. Simulation studies indicate that resveratrol and its analogs/ derivatives show good interaction with the target receptor through its hydroxyl groups by forming hydrogen bonds and hydrophobic interactions with amino acid residues at the binding site. Binding geometry and stability of complex formed by resveratrol show that it is a good inhibitor for many pathogenic targets. Further studies in this direction is, however, the need of the hour to develop many more ligands based on resveratrol skeleton which can further serve in the treatment of ailments.
几种酚类化合物与蛋白质（如酶）结合，并干扰其催化机制。本文综述了天然多酚白藜芦醇与微管蛋白、蛋白激酶 C 阿尔法（PKCα）、磷酸二酯酶-4D、人口腔癌细胞系蛋白质、具有 AATT/TTAA 片段的 DNA 序列、蛋白激酶 C 阿尔法、赖氨酸特异性去甲基化酶 1 等各种靶标的相互作用研究。模拟研究表明，白藜芦醇及其类似物/衍生物通过其羟基与靶受体形成氢键，并与结合位点的氨基酸残基形成疏水相互作用，从而与靶受体良好相互作用。白藜芦醇形成的复合物的结合几何形状和稳定性表明，它是许多致病靶标的良好抑制剂。然而，在这一方向上进一步的研究是必要的，以开发更多基于白藜芦醇骨架的配体，这些配体可以进一步用于治疗疾病。
