利用人脱落乳牙干细胞（SHED）的再生医学：小儿外科一种有前景的新疗法。
Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery.
作者信息
Taguchi Tomoaki, Yanagi Yusuke, Yoshimaru Koichiro, Zhang Xiu-Ying, Matsuura Toshiharu, Nakayama Koichi, Kobayashi Eiji, Yamaza Haruyoshi, Nonaka Kazuaki, Ohga Shouichi, Yamaza Takayoshi
机构信息
Department of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine, Saga University, Honjyo 1-chome, Honjyo-cho, Saga, 840-8502, Japan.
出版信息
Surg Today. 2019 Apr;49(4):316-322. doi: 10.1007/s00595-019-01783-z. Epub 2019 Mar 5.
Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.
人乳牙脱落干细胞（SHEDs）作为一种间充质干细胞，是再生医学理想的细胞来源。它们的致癌风险极小，具有高增殖能力、高多能性和免疫抑制能力。已发现使用SHED进行干细胞移植对小鼠肝纤维化具有抗纤维化作用。SHED移植以及能够创建肝脏和膈肌无支架三维图像的生物3D打印机，为诸如胆道闭锁和膈疝等难治性小儿外科疾病提供了一种新的创新治疗方式。
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