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年轻成人急性髓细胞白血病患者采用维奈托克联合小剂量阿糖胞苷行门诊造血干细胞移植:两例报告。

Ambulatory Hematopoietic Stem Cell Transplantation in Young Adults with Acute Myeloid Leukemia Treated with Venetoclax and Low Doses of Cytarabine: Report of Two Cases.

机构信息

1Hematology Service, Hospital Civil de Guadalajara "Dr. Juan I. Menchaca," Guadalajara, Mexico.

2Centro Universitario de Tonala, Universidad de Guadalajara, Tonala, Mexico.

出版信息

J Adolesc Young Adult Oncol. 2019 Aug;8(4):481-483. doi: 10.1089/jayao.2018.0137. Epub 2019 Mar 4.

Abstract

Acute myelogenous leukemia (AML) represents ∼33% of those in adolescents and young adults. Hematopoietic cell transplantation in its various practices has been used as a treatment for acute myeloid leukemia, especially in refractory or relapsing patients. In this study, we describe two young adults with AML who were treated at our hospital. One was refractory to conventional treatment and the other case was relapsed after a first complete remission. They achieved complete remission with new combined treatment (venetoclax + cytarabine) consolidating them with hematopoietic stem cell transplantation.

摘要

急性髓细胞白血病(AML)占青少年和年轻成人的约 33%。各种造血细胞移植已被用于治疗急性髓系白血病,特别是在难治性或复发性患者中。在本研究中,我们描述了在我院接受治疗的两名 AML 年轻成人患者。一名患者对常规治疗无效,另一名患者在首次完全缓解后复发。他们通过新的联合治疗(venetoclax + 阿糖胞苷)获得完全缓解,并进行造血干细胞移植巩固治疗。

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