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The influence of OKT8F treatment on allograft survival in rhesus monkeys.

作者信息

Jonker M, Nooij F J, van Suylichem P, Neuhaus P, Goldstein G

出版信息

Transplantation. 1986 Apr;41(4):431-5. doi: 10.1097/00007890-198604000-00004.

DOI:10.1097/00007890-198604000-00004
PMID:3083541
Abstract

The immunosuppressive effect of a monoclonal antibody specific for the cytotoxic/suppressor T cells (CD8) was investigated in rhesus monkeys. This antibody (OKT8F) removed the CD8-positive T cells from the circulation and prolonged skin allograft survival. Since most patients awaiting a kidney allograft are transfused prior to transplantation, the immunosuppressive potency of OKT8F was subsequently investigated in transfused recipients. No significant prolongation of the mean survival time was observed when OKT8F was given prophylactically. However, no early rejections were observed, while 30% of the control animals rejected their kidneys within 2 weeks. This might indicate that OKT8F prevents early rejection of a kidney allograft in transfused recipients.

摘要

相似文献

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The influence of OKT8F treatment on allograft survival in rhesus monkeys.
Transplantation. 1986 Apr;41(4):431-5. doi: 10.1097/00007890-198604000-00004.
2
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Effects of CD4 and CD8 specific monoclonal antibodies in vitro and in vivo on T cells and their relation to the allograft response in rhesus monkeys.
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Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primates.用人源化抗CD154单克隆抗体hu5C8进行治疗，可预防非人灵长类动物原发性皮肤同种异体移植物的急性排斥反应。
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Treatment of rhesus monkey allograft recipients with a combination of anti-T-cell monoclonal antibodies.用抗T细胞单克隆抗体组合治疗恒河猴同种异体移植受体。
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No synergy between ATG induction and costimulation blockade induced kidney allograft survival in rhesus monkeys.在恒河猴中，抗胸腺细胞球蛋白诱导与共刺激阻断之间不存在协同作用以延长肾移植存活时间。
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Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.用供体特异性输血和抗CD154抗体治疗同种异体移植受者会导致同种异体反应性CD8 + T细胞缺失，并以CTLA4依赖的方式延长移植物存活时间。
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Blood-transfusions induce prolonged kidney allograft survival in rhesus monkeys.
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Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.在感染猿猴免疫缺陷病毒的猕猴中，CD8(+) T细胞耗竭后血浆病毒血症急剧上升。
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