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从真菌中分离得到的两个新三萜类化合物。

Two new triterpenoids from the fungus .

机构信息

Key Laboratory of Chemical Biology (Ministry of Education) Department of Natural Product Chemistry School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China.

The Second Hospital of Shandong University, Jinan, P. R. China.

出版信息

Nat Prod Res. 2020 Aug;34(15):2179-2185. doi: 10.1080/14786419.2019.1578762. Epub 2019 Mar 5.

Abstract

One new pentanortriterpenoid, 23,24,25,26,27-pentanorlanost-7,9(11)-dien-3β,22-diol (), one new triterpenoid, lanost-8-en-3β,22,23-triol (), together with the known triterpenoid, 23,24,25,26,27-pentanorlanost-8-en-3β,22-diol (), were obtained from culture of the fungus associated with the moss . The structures of the new compounds were elucidated by extensive spectroscopic techniques including HR-ESIMS and 1 D and 2 D NMR experiments. The cytotoxicity of these compounds against human cancer cell lines (A549, Hep G2, Hepa 1c1c7, and Hela) was evaluated and compound exhibited weak inhibitory activity with IC value of 35.0 ± 2.3 μM against the proliferation of the Hepa 1c1c7 cells.

摘要

一种新的五环三萜类化合物,23,24,25,26,27-五去甲兰烷-7,9(11)-二烯-3β,22-二醇(),一种新的三萜类化合物,兰烷-8-烯-3β,22,23-三醇(),以及已知的三萜类化合物,23,24,25,26,27-五去甲兰烷-8-烯-3β,22-二醇(),从与苔藓相关的真菌中培养获得。新化合物的结构通过广泛的光谱技术包括高分辨率电喷雾电离质谱(HR-ESIMS)和 1D 和 2D NMR 实验来阐明。这些化合物对人癌细胞系(A549、Hep G2、Hepa 1c1c7 和 Hela)的细胞毒性进行了评估,化合物表现出微弱的抑制活性,对 Hepa 1c1c7 细胞增殖的 IC 值为 35.0±2.3μM。

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