Hu Jiang, Song Yan, Yang Benshou, Zuo Xiang, Mao Xiao, Shi Xiaodong
College of Biological Resources and Environment Science, Qujing Normal University, Sanjiang Avenue, Unicorn District, Qujing, 655011, Yunnan Province, China,
Arch Pharm Res. 2014 Dec;37(12):1515-21. doi: 10.1007/s12272-014-0428-z. Epub 2014 Jul 1.
Three new triterpenoids, 11α-hydroxy-lup-20(29)-ene-3β-palmitate (1), 28-hydroxy-20-oxo-30-norlupane-3β-palmitate (2), and 1β,11α,28-tyrihydroxy oleana-9(11),12-dien-3β-palmitate (3), together with three known compounds were isolated from the 95 % EtOH extract of Saussurea phyllocephala. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. All the triterpenoids were in vitro evaluated for their cytotoxic activities. Compound 1-3 exhibited the significant cytotoxic activities with low IC50 values (IC50 < 4.0 μM) against six tumor cell lines (MCF-7, HeLa, HepG2, SGC-7901, NCI-H460 and BGC-823).
从苞叶风毛菊95%乙醇提取物中分离得到3个新的三萜类化合物，11α-羟基羽扇-20(29)-烯-3β-棕榈酸酯（1）、28-羟基-20-氧代-30-降羽扇烷-3β-棕榈酸酯（2）和1β,11α,28-三羟基齐墩果-9(11),12-二烯-3β-棕榈酸酯（3），以及3个已知化合物。通过一维和二维核磁共振（COSY、HMQC、HMBC和NOESY）分析确定了新化合物的结构。对所有三萜类化合物进行了体外细胞毒性活性评价。化合物1-3对6种肿瘤细胞系（MCF-7、HeLa、HepG2、SGC-7901、NCI-H460和BGC-823）表现出显著的细胞毒性活性，IC50值较低（IC50 < 4.0 μM）。
