Bowman J M
Vox Sang. 1986;50(2):104-6. doi: 10.1111/j.1423-0410.1986.tb04855.x.
Ninety-one of 330 fetuses undergoing intrauterine fetal transfusion (IUT) had sufficient residual fetal red cells in their cord blood samples that their AB0 blood groups could be determined. Ten of the 91 (11%) were AB0 incompatible with their mothers. The degree of Rh disease was severe in all 10. Three were hydropic in utero; 5 had the syndrome of hepatocellular damage; in 6, IUT were required between 22 and 26 weeks gestation. The expected incidence of AB0 incompatible pregnancies in which the fetuses required IUT if AB0 incompatibility had no effect on severity of Rh disease, is 9.7% versus the 11% observed. AB0 incompatibility has no effect on ameliorating severity of erythroblastosis after Rh immunization has developed. AB0 incompatibility between mother and father should not be taken into account when making decisions regarding the management of an Rh immunized pregnancy.
在接受宫内胎儿输血(IUT)的330例胎儿中,有91例其脐带血样本中留有足够的胎儿红细胞,从而能够确定其ABO血型。这91例中有10例(11%)与母亲ABO血型不相容。所有10例的Rh疾病程度都很严重。3例在子宫内出现水肿;5例有肝细胞损伤综合征;6例在妊娠22至26周期间需要进行宫内胎儿输血。如果ABO血型不相容对Rh疾病的严重程度没有影响,那么对于需要宫内胎儿输血的胎儿,ABO血型不相容妊娠的预期发生率为9.7%,而观察到的发生率为11%。在Rh免疫形成后,ABO血型不相容对改善成红细胞增多症的严重程度没有作用。在对Rh免疫妊娠进行管理决策时,不应考虑父母之间的ABO血型不相容情况。