“相关”的 Aβ42 浓度是多少？
What Is the "Relevant" Amyloid β42 Concentration?
机构信息
Department of Chemistry and Biochemistry, University of California Santa Cruz, Physical Science Building 356, 1156 High Street, Santa Cruz, CA, 95064, USA.
出版信息
Chembiochem. 2019 Jul 1;20(13):1725-1726. doi: 10.1002/cbic.201900097. Epub 2019 May 17.
Abstract
Alzheimer's amyloid beta can perform a wide variety of actions that are highly concentration dependent. This viewpoint aims to provide a framework for basic considerations on what might be considered brain-relevant concentrations of the peptide. Some implications for the therapeutic implementation of the recently emerged oligomer-to-fibril strategy are discussed.
摘要
阿尔茨海默病淀粉样β蛋白可以执行多种高度依赖浓度的作用。这一观点旨在为考虑肽的脑相关浓度提供一个基本框架。还讨论了最近出现的寡聚体到纤维策略的治疗实施的一些影响。
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