Hasegawa Hiroaki, Sato Masanori
Department of Radiology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo 113-8655, Japan.
Department of Radiological Sciences, Faculty of Health Sciences, Komazawa University, Setagaya-ku, Tokyo 154-8525, Japan.
Diagnostics (Basel). 2019 Mar 4;9(1):27. doi: 10.3390/diagnostics9010027.
In regenerative medicine, evaluation of bone mineral density using a microfocus X-ray generator could eventually be used to determine the degree of bone tissue regeneration. To evaluate bone mineral density against regenerated bone material, two low-energy X-rays are necessary. Herein, the acquisition of quasi-monochromatic, dual-energy soft X-ray and the subsequent medical application were examined using the K-absorption edges of two types of metal filters (i.e., zirconium and tin) in a microfocus X-ray generator. Investigation of the optimal tube voltage and filter thickness to form a quasi-monochromatic energy spectrum with a single filter revealed that a filter thickness of 0.3 mm results in an optimal monochromatization state. When a dual filter was used, the required filter thickness was 0.3 mm for tin and 0.2 mm for zirconium at a tube voltage of 35 kV. For the medical application, we measured quasi-monochromatic, dual-energy X-rays to evaluate the measurement accuracy of bone mineral density. Using aluminum as a simulated bone sample, a relative error of ≤5% was consistent within the aluminum thickness range of 1⁻3 mm. These data suggest that a bone mineral density indicator of recycled bone material can be easily obtained with the quasi-monochromatic X-ray technique using a microfocus X-ray generator.
在再生医学中，使用微焦点X射线发生器评估骨密度最终可能用于确定骨组织再生的程度。为了评估再生骨材料的骨密度，需要两种低能X射线。在此，利用微焦点X射线发生器中两种金属滤光片（即锆和锡）的K吸收边，研究了准单色双能软X射线的获取及其后续医学应用。对使用单个滤光片形成准单色能谱的最佳管电压和滤光片厚度的研究表明，0.3毫米的滤光片厚度可实现最佳单色化状态。当使用双滤光片时，在35 kV的管电压下，锡所需的滤光片厚度为0.3毫米，锆为0.2毫米。对于医学应用，我们测量了准单色双能X射线以评估骨密度测量的准确性。使用铝作为模拟骨样本，在1至3毫米的铝厚度范围内，相对误差≤5%是一致的。这些数据表明，使用微焦点X射线发生器的准单色X射线技术可以轻松获得再生骨材料的骨密度指标。
