使用神经元特异性烯醇化酶预测颌面部骨折的摩托车事故患者的轻度脑损伤：一项初步研究。
Use of neuron-specific enolase to predict mild brain injury in motorcycle crash patients with maxillofacial fractures: A pilot study.
作者信息
Ruslin Muhammad, Wolff Jan, Yusuf Harmas Yazid, Arifin Muhammad Zaifullah, Boffano Paolo, Forouzanfar Tymour
机构信息
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia; Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center/Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, the Netherlands.
Department of Oral and Maxillofacial Surgery/Oral Pathology, VU University Medical Center/Academic Center for Dentistry Amsterdam (ACTA), Amsterdam, the Netherlands.
出版信息
Chin J Traumatol. 2019 Feb;22(1):47-50. doi: 10.1016/j.cjtee.2018.12.004. Epub 2019 Feb 10.
PURPOSE
Mild traumatic brain injury (TBI) is common but accurate diagnosis and its clinical consequences have been a problem. Maxillofacial trauma does have an association with TBI. Neuron-specific enolase (NSE) has been developed to evaluate neuronal damage. The objective of this study was to investigate the accuracy of NSE serum levels to detect mild brain injury of patients with sustained maxillofacial fractures during motor vehicle accidents.
METHODS
Blood samples were drawn from 40 healthy people (control group) and 48 trauma patients who had sustained isolated maxillofacial fractures and mild brain injury in motor vehicle accidents. Brain injuries were graded by Glasgow Coma Scale. In the trauma group, correlations between the NSE serum value and different facial fracture sites were also assessed.
RESULTS
The NSE serum level (mean ± SD, ng/ml) in the 48 patients with maxillofacial fractures and mild TBI was 13.12 ± 9.68, significantly higher than that measured in the healthy control group (7.72 ± 1.82, p < 0.001). The mean NSE serum level (ng/ml) in the lower part of the facial skeleton (15.44 with SD 15.34) was higher than that in the upper facial part (12.42 with SD 7.68); and the mean NSE level (ng/ml) in the middle-and lower part (11.97 with SD 5.63) was higher than in the middle part (7.88 with SD 2.64).
CONCLUSION
An increase in NSE serum levels can be observed in patients sustained maxillofacial fractures and mild brain injury.
目的
轻度创伤性脑损伤（TBI）很常见，但准确诊断及其临床后果一直是个问题。颌面创伤与TBI确实存在关联。神经元特异性烯醇化酶（NSE）已被用于评估神经元损伤。本研究的目的是调查NSE血清水平检测机动车事故中颌面部持续骨折患者轻度脑损伤的准确性。
方法
从40名健康人（对照组）和48名在机动车事故中遭受孤立性颌面部骨折和轻度脑损伤的创伤患者中采集血样。脑损伤采用格拉斯哥昏迷量表进行分级。在创伤组中，还评估了NSE血清值与不同面部骨折部位之间的相关性。
结果
48例颌面部骨折合并轻度TBI患者的NSE血清水平（平均值±标准差，ng/ml）为13.12±9.68，显著高于健康对照组（7.72±1.82，p<0.001）。面部骨骼下部的平均NSE血清水平（ng/ml）（15.44，标准差为15.34）高于面部上部（12.42，标准差为7.68）；中下部的平均NSE水平（ng/ml）（11.97，标准差为5.63）高于中部（7.88，标准差为2.64）。
结论
颌面部骨折合并轻度脑损伤患者可观察到NSE血清水平升高。
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