Peris Vidal A, Hernández Marco R, Escribano Montaner A, Aparisi Ibáñez M, Alós Almiñana M
An Esp Pediatr. 1986 Feb;24(2):111-7.
Zinc balances were performed in five different occasions in three children receiving prolonged total parenteral nutrition (TPN) for 4 or more weeks. Excessive urinary zinc loss was a constant finding and one patient also presented increased fecal loss. It is concluded that TPN solutions when administered for long periods must be supplemented with zinc in order to obtain positive balances and a retention of zinc between 50-100 micrograms kg/day. In children without abnormal losses supplements recommended by the American Medical Association (100 micrograms/kg/day up to 5 years and from 2.5 to 4 mg/day in old children) seem adequate. In case of deficit in Zn and/or high digestive losses supplement of Zn in TPN must be increased up to 200 to 500 micrograms/kg/day.
对三名接受长期全胃肠外营养（TPN）达4周或更长时间的儿童，在五个不同时段进行了锌平衡研究。持续发现尿锌过度流失，且一名患者还出现粪便锌流失增加。得出结论，长期使用的TPN溶液必须补充锌，以实现正平衡并使锌潴留量达到50 - 100微克/千克/天。对于无异常锌流失的儿童，美国医学协会推荐的补充量（5岁以下儿童为100微克/千克/天，大龄儿童为2.5至4毫克/天）似乎足够。在锌缺乏和/或消化液锌流失量高的情况下，TPN中的锌补充量必须增加至200至500微克/千克/天。
