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Affinity isolation of the interleukin-3 surface receptor.

作者信息

May W S, Ihle J N

出版信息

Biochem Biophys Res Commun. 1986 Mar 28;135(3):870-9. doi: 10.1016/0006-291x(86)91009-0.

DOI:10.1016/0006-291x(86)91009-0
PMID:3083813
Abstract

Interleukin-3 (IL-3) is a pluripotent hematopoietic growth factor which can stimulate both proliferation and differentiation of progenitor cells. Using the factor dependent NSF-60 and FDC-P1 cells, which possess specific, high affinity binding sites for 125I-IL-3 (i.e. KD 9.5 and 10.7 X 10(-11)M, respectively) the IL-3 surface receptor has been isolated. Using two separate affinity techniques the IL-3 receptor identified from both cell types was invariant. The IL-3 receptor is a protein of molecular weight 65-70,000 daltons.

摘要

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