Murakami Yasukiyo, Fujita Tetsuo, Wakatabe Yoji, Iwamura Masatsugu
Department of Urology, Kitasato University School of Medicine, Japan.
Case Rep Urol. 2019 Jan 31;2019:2703871. doi: 10.1155/2019/2703871. eCollection 2019.
We describe an 81-year-old woman with metastatic renal cell carcinoma who did not recover from life-threatening interstitial pneumonitis induced by everolimus therapy. She received everolimus due to disease progression after sunitinib, but 2 months after starting everolimus treatment, she visited the emergency department after developing a sudden fever and dyspnea. Chest CT revealed diffuse ground-glass opacities, thickening of the interlobular septa, and consolidation throughout both lung fields. The diagnosis was surmised to be everolimus-induced interstitial pneumonitis. Everolimus administration was stopped and 3 courses of steroid pulse therapy were administered, along with intensive care, but the patient died due to rapid respiratory failure.
我们描述了一名81岁的转移性肾细胞癌女性患者，她未能从依维莫司治疗引发的危及生命的间质性肺炎中康复。她在舒尼替尼治疗后疾病进展，因此接受了依维莫司治疗，但在开始依维莫司治疗2个月后，她在出现突发发热和呼吸困难后前往急诊科就诊。胸部CT显示双肺野弥漫性磨玻璃影、小叶间隔增厚及实变。推测诊断为依维莫司诱发的间质性肺炎。停用依维莫司，并给予3个疗程的糖皮质激素冲击治疗及重症监护，但患者因快速呼吸衰竭死亡。
