Department of Orthopedic Oncology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China.
Department of Radiology, Changzheng Hospital, Secondary Military Medical University, Shanghai, China.
Eur Spine J. 2019 Jun;28(6):1537-1545. doi: 10.1007/s00586-019-05920-7. Epub 2019 Mar 5.
The aim of the study was to report the long-term outcomes and analyze the potential prognostic factors that may contribute to symptomatic patients with aneurysmal bone cyst (ABC) of the spine undergoing surgical treatments.
A retrospective analysis of consecutive patients with ABCs of the spine was performed. The clinical features were reviewed, and the disease-free survival (DFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method. Factors with p values ≤ 0.05 were subjected to multivariate analysis by Cox proportional hazards model to identify the independent prognostic contributors. p values < 0.05 were considered statistically significant.
A total of 42 patients with ABCs of the spine were included in the study. All patients received surgical treatments. The mean follow-up period was 41.3 months (median 39.5, range 24-64). Local recurrence was detected in eight patients after surgery in our center, whereas death occurred in three patients. The estimated 5-year DFS and OS rate was 54.1% and 76.8%, respectively. The statistical analyses indicated that both en bloc resection and primary/secondary tumor status were independent prognostic factors for DFS.
Secondary ABC status may be associated with worse prognosis, and en bloc resection remains the treatment of choice for ABCs with neurologic deficits or spinal instability of the spine, which is correlated with better prognosis for local tumor control. These slides can be retrieved under Electronic Supplementary Material.
本研究旨在报告接受手术治疗的症状性脊柱动脉瘤样骨囊肿（ABC）患者的长期结果，并分析可能影响其预后的潜在因素。
对连续的脊柱 ABC 患者进行回顾性分析。回顾了临床特征，并使用 Kaplan-Meier 法估计无病生存率（DFS）和总生存率（OS）。将 p 值≤0.05 的因素通过 Cox 比例风险模型进行多因素分析，以确定独立的预后因素。p 值<0.05 被认为具有统计学意义。
本研究共纳入 42 例脊柱 ABC 患者。所有患者均接受手术治疗。平均随访时间为 41.3 个月（中位数 39.5，范围 24-64）。在本中心手术后，有 8 例患者局部复发，有 3 例患者死亡。估计 5 年 DFS 和 OS 率分别为 54.1%和 76.8%。统计学分析表明，整块切除和原发性/继发性肿瘤状态均是 DFS 的独立预后因素。
继发性 ABC 状态可能与预后不良相关，而整块切除仍然是治疗伴有神经功能缺损或脊柱不稳定的脊柱 ABC 的首选方法，与局部肿瘤控制的更好预后相关。这些幻灯片可在电子补充材料中检索。
