Lochmann Dee, Richardson Tara
Psychiatry and Behavioral Sciences, University of Kansas School of Medicine-Wichita, Wichita, KS, USA.
Handb Exp Pharmacol. 2019;250:135-144. doi: 10.1007/164_2018_172.
The first antidepressants were created by chance but brought the idea that central serotonin agonism produced an antidepressant effect. SSRIs were the first class of psychotropic medications to be rationally designed, meaning that researchers intended to utilize a specific mechanism of action while avoiding adverse effects. In this way, SSRIs were created to be safer and more tolerable than previous antidepressants. SSRIs share many similarities, but differ in terms of pharmacokinetics and effects on CYP450 enzymes, which is detailed in this chapter. Further information will be provided regarding safety, clinical indications/uses, and dosing recommendations.
第一代抗抑郁药是偶然发现的，但由此产生了一种观点，即中枢5-羟色胺激动作用可产生抗抑郁效果。选择性5-羟色胺再摄取抑制剂（SSRI）是首批经过合理设计的精神药物，这意味着研究人员旨在利用特定的作用机制，同时避免不良反应。通过这种方式，SSRI被设计得比以往的抗抑郁药更安全、更易耐受。SSRI有许多相似之处，但在药代动力学和对细胞色素P450酶的影响方面存在差异，本章将对此进行详细阐述。还将提供有关安全性、临床适应症/用途和给药建议的更多信息。
