Zhao Dan, Wang Bing, Cai Ailu
Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China.
J Clin Ultrasound. 2019 Sep;47(7):394-398. doi: 10.1002/jcu.22722. Epub 2019 Mar 5.
This study was undertaken to evaluate the performance of indirect sonographic signs in detecting partial agenesis of the corpus callosum (pACC) at midgestation, focusing on the cavum septum pellucidum (CSP) ratio.
A retrospective case-controlled study of singleton pregnancies was conducted, examining fetuses diagnosed with isolated pACC and normal controls. At midgestational age, fetal head volumes were imaged with 3D US and stored for the evaluation of indirect sonographic findings in axial planes.
Fifteen normal and 15 abnormal fetuses (with pACC) were analyzed. Based on a CSP ratio < 1.5, detection of pACC increased from 66.7% (10/15) to 80% (12/15). All indirect signs proved highly suspicious for pACC (risk ratios > 1).
Use of indirect sonographic signs to screen for pACC at midgestation is challenging. However, a low CSP ratio may improve the detection rate, serving as a new indirect sign.
本研究旨在评估间接超声征象在孕中期检测胼胝体部分发育不全（pACC）中的表现，重点关注透明隔腔（CSP）比率。
对单胎妊娠进行回顾性病例对照研究，检查诊断为孤立性pACC的胎儿和正常对照。在孕中期，用三维超声对胎儿头部容积进行成像，并存储用于评估轴向平面的间接超声检查结果。
分析了15例正常胎儿和15例异常胎儿（患有pACC）。基于CSP比率<1.5，pACC的检测率从66.7%（10/15）提高到80%（12/15）。所有间接征象对pACC均高度可疑（风险比率>1）。
在孕中期使用间接超声征象筛查pACC具有挑战性。然而，低CSP比率可能提高检测率，可作为一种新的间接征象。
