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评估硬皮病临床试验联合会关于硬皮病改良 Rodnan 皮肤评分评估的培训建议。

Evaluation of Scleroderma Clinical Trials Consortium training recommendations on modified Rodnan skin score assessment in scleroderma.

机构信息

Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore.

Duke-National University of Singapore, Singapore, Singapore.

出版信息

Int J Rheum Dis. 2019 Jun;22(6):1036-1040. doi: 10.1111/1756-185X.13523. Epub 2019 Mar 6.

Abstract

AIM

The modified Rodnan skin score (mRSS) is a validated outcome measure for skin thickness in systemic sclerosis (SSc). Training has been shown to reduce variability in the measurement of mRSS. Our objective was to assess the inter- and intra-observer variability of mRSS scoring using the proposed recommendations for training by the Scleroderma Clinical Trials Consortium (SCTC) and World Scleroderma Foundation (WSF).

METHOD

Fifty-two trainees and eight adult SSc patients participated in the SSc skin scoring workshop that was conducted in two sessions by four teachers. Each session, attended by 26 trainees, had a teaching and evaluation phase. The teaching phase comprised of: (a) lecture on mRSS scoring; (b) video demonstration of mRSS scoring; and (c) live demonstration of mRSS on one SSc patient. In the evaluation phase, each trainee independently assessed the mRSS in four SSc patients. For intra-observer reliability, 14 trainees re-assessed the mRSS of two SSc patients whom they had previously examined. We computed the inter- and intra-observer variability using a linear mixed model.

RESULTS

For the evaluation phase, 34 (65.4%) trainees were within five units of the established teachers' score in 3 out of 4 patients. Overall, the whole group had acceptable inter-observer variability (intra-class correlation coefficient [ICC] = 0.71, mean = 8.64 and within-patient standard deviation [SD] = 4.25). The intra-observer ICC was 0.85 and within-patient SD was 2.73.

CONCLUSION

There was good inter-observer and excellent intra-observer reliability. This is the first study examining the training of assessors using the SCTC/WSF recommendations and our results support the importance of standardized training for skin scoring.

摘要

目的

改良的罗德南皮肤评分(mRSS)是系统性硬化症(SSc)皮肤厚度的一种经过验证的结局测量指标。培训已被证明可降低 mRSS 测量的变异性。我们的目的是评估使用 Scleroderma Clinical Trials Consortium(SCTC)和 World Scleroderma Foundation(WSF)提出的培训建议对 mRSS 评分的观察者间和观察者内变异性。

方法

52 名学员和 8 名成年 SSc 患者参加了由 4 位教师分两期进行的 SSc 皮肤评分研讨会。每期有 26 名学员参加,包括教学和评估两个阶段。教学阶段包括:(a)mRSS 评分讲座;(b)mRSS 评分视频演示;和(c)对一名 SSc 患者进行 mRSS 现场演示。在评估阶段,每位学员独立评估了 4 名 SSc 患者的 mRSS。为了评估观察者内的可靠性,14 名学员重新评估了他们之前检查过的两名 SSc 患者的 mRSS。我们使用线性混合模型计算了观察者间和观察者内的变异性。

结果

在评估阶段,34 名(65.4%)学员在 4 名患者中的 3 名中,与既定教师评分相差 5 分以内。总体而言,整个组的观察者间变异性可接受(组内相关系数[ICC]为 0.71,平均值为 8.64,患者内标准差[SD]为 4.25)。观察者内 ICC 为 0.85,患者内 SD 为 2.73。

结论

存在良好的观察者间和极好的观察者内可靠性。这是第一项使用 SCTC/WSF 建议评估评估者培训的研究,我们的结果支持皮肤评分标准化培训的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a67/6635739/c6ade49f40b3/APL-22-1036-g001.jpg

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