一锅法开环/闭环串联反应合成多环螺环吲哚。
A One-Pot Ring-Opening/Ring-Closure Sequence for the Synthesis of Polycyclic Spirooxindoles.
机构信息
College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, P.R. China.
College of Chemistry and Materials Science, Nanning Normal University, Nanning, 530001, Guangxi, P.R. China.
出版信息
Chemistry. 2019 Mar 27;25(18):4673-4677. doi: 10.1002/chem.201900409. Epub 2019 Mar 6.
PMID:30840339
Abstract
One-pot ring-opening/ring-closure process of combining methyleneindolinone with 3-aminooxindole has been developed in this work. Novel polycyclic spirooxindoles were efficiently assembled under mild conditions in high yields (up to 95 %) with moderate to good diastereoselectivities (up to >95:5 d.r.) through simple filtration.
摘要
在这项工作中，开发了一种将亚甲基吲哚啉酮与 3-氨基氧吲哚结合的一锅开环/闭环过程。新型多环螺环氧化吲哚在温和条件下通过简单过滤以高产率（高达 95%）和中等至良好的非对映选择性（高达>95:5 d.r.）高效组装。
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