Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamilnadu, 632014, India.
Mol Divers. 2022 Aug;26(4):2311-2339. doi: 10.1007/s11030-021-10322-3. Epub 2021 Oct 27.
The use of montmorillonite clay as solid catalyst has grabbed much attention in the liquid phase reactions for organic synthesis. In recent years, there has been a lot of interest in organic synthesis using montmorillonite-based composites, especially in the synthesis of heterogeneous nanoparticles. Due to the robust and green nature of montmorillonite-based nanocatalysts, it has been widely used in N-heterocyclic reactions. In this review, we have concentrated on the reports pertaining the use of montmorillonite-based nanocatalyst in the synthesis of N-heterocycles, a category of organic compounds with excellent biological properties. This manuscript is arranged by the types of N-containing heterocycles synthesized using montmorillonite-based composite as catalysts including polycyclic spirooxindoles, heterocyclic propargylamine, indole-based heterocycles, quinoline and its derivatives, six-membered N-heterocyclic-based compounds and five-membered N-heterocyclic-based compounds. Special attention was given to the structural stability under experimental parameters of the montmorillonite-based composite with the incidence of metal leaching and reusability. Finally, along with recent developments, new findings in heterogeneous montmorillonite (Mt)-based catalysis have also been addressed.
蒙脱石粘土作为固体催化剂在有机合成的液相反应中引起了广泛关注。近年来，人们对基于蒙脱石的复合材料在有机合成中的应用产生了浓厚的兴趣，特别是在异相纳米粒子的合成方面。由于基于蒙脱石的纳米催化剂具有坚固和绿色的性质，因此它已被广泛应用于 N-杂环反应中。在这篇综述中，我们集中讨论了使用基于蒙脱石的纳米催化剂合成 N-杂环的报告，N-杂环是一类具有优异生物性质的有机化合物。本文按照使用基于蒙脱石的复合材料作为催化剂合成的 N-杂环的类型进行组织，包括多环螺[吲哚啉-3,3′-吡咯烷]、杂环丙炔胺、吲哚基杂环、喹啉及其衍生物、六元 N-杂环化合物和五元 N-杂环化合物。特别关注了实验参数下金属浸出和可重复使用性对基于蒙脱石的复合材料结构稳定性的影响。最后，结合最新的发展，还讨论了非均相蒙脱石（Mt）基催化的新发现。
