Bao Ming, Wang Xin, Qiu Lihua, Hu Wenhao, Hong Chan Philip Wai, Xu Xinfang
School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou , 510006 , China.
College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou 215123 , China.
Org Lett. 2019 Mar 15;21(6):1813-1817. doi: 10.1021/acs.orglett.9b00392. Epub 2019 Mar 6.
An efficient gold(I)-catalyzed carbocyclization reaction for the synthesis of isomycin derivatives from propargyl diazoacetates has been developed. The suggested cyclization pathway delineated the first example of a vinyl gold carbenoid species generated in situ from gold(I)-catalyzed 1,2-acyloxy migration and intercepted by a cross-coupling reaction with the remaining tethered diazo functionality. The use of protic additives was essential to regulating the reaction outcome by fine-tuning the catalytic preference of the gold(I) complex.
已开发出一种高效的金（I）催化的环化反应，用于从炔丙基重氮乙酸酯合成异霉素衍生物。所提出的环化途径描绘了通过金（I）催化的1,2 - 酰氧基迁移原位生成并通过与剩余连接的重氮官能团的交叉偶联反应截获的乙烯基金卡宾物种的第一个实例。质子添加剂的使用对于通过微调金（I）配合物的催化偏好来调节反应结果至关重要。
