Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Republic of Korea.
Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, Republic of Korea.
PLoS One. 2019 Mar 6;14(3):e0210159. doi: 10.1371/journal.pone.0210159. eCollection 2019.
Type 2 diabetes mellitus (T2DM) is a chronic disease that requires long-term therapy and regular check-ups to prevent complications. In this study, insurance claim data from the National Health Insurance Service (NHIS) of Korea were used to investigate insulin use in T2DM patients according to the economic status of patients and their access to primary physicians, operationally defined as the frequently used medical care providers at the time of T2DM diagnosis. A total of 91,810 participants were included from the NHIS claims database for the period between 2002 and 2013. The utilization pattern of insulin was set as the dependent variable and classified as one of the following: non-use of antidiabetic drugs, use of oral antidiabetic drugs only, or use of insulin with or without oral antidiabetic drugs. The main independent variables of interest were level of income and access to a frequently-visited physician. Multivariate Cox proportional hazards analysis was performed. Insulin was used by 9,281 patients during the study period, while use was 2.874 times more frequent in the Medical-aid group than in the highest premium group [hazard ratio (HR): 2.874, 95% confidence interval (CI): 2.588-3.192]. Insulin was also used ~50% more often in the patients managed by a frequently-visited physician than in those managed by other healthcare professionals (HR: 1.549, 95% CI: 1.434-1.624). The lag time to starting insulin was shorter when the patients had a low income and no frequently-visited physicians. Patients with a low level of income were more likely to use insulin and to have a shorter lag time from diagnosis to starting insulin. The likelihood of insulin being used was higher when the patients had a frequently-visited physician, particularly if they also had a low level of income. Therefore, the economic statuses of patients should be considered to ensure effective management of T2DM. Utilizing frequently-visited physicians might improve the management of T2DM, particularly for patients with a low income.
2 型糖尿病(T2DM)是一种需要长期治疗和定期检查的慢性病,以预防并发症。本研究使用韩国国家健康保险服务(NHIS)的保险索赔数据,根据患者的经济状况和他们获得初级保健医生的情况(操作上定义为 T2DM 诊断时经常使用的医疗保健提供者),调查 T2DM 患者使用胰岛素的情况。从 2002 年至 2013 年,从 NHIS 索赔数据库中纳入了 91810 名参与者。胰岛素使用模式被设定为因变量,并分为以下几种情况:不使用抗糖尿病药物、仅使用口服抗糖尿病药物或使用胰岛素加或不加口服抗糖尿病药物。主要感兴趣的自变量是收入水平和获得经常就诊医生的机会。进行了多变量 Cox 比例风险分析。在研究期间,有 9281 名患者使用了胰岛素,而医疗补助组的使用率比最高保费组高 2.874 倍[风险比(HR):2.874,95%置信区间(CI):2.588-3.192]。与由其他医疗保健专业人员管理的患者相比,由经常就诊医生管理的患者使用胰岛素的频率也高出约 50%(HR:1.549,95%CI:1.434-1.624)。收入较低且没有经常就诊医生的患者开始使用胰岛素的滞后时间更短。收入水平较低的患者更有可能使用胰岛素,并且从诊断到开始使用胰岛素的滞后时间更短。当患者有经常就诊的医生时,使用胰岛素的可能性更高,特别是当他们的收入也较低时。因此,应考虑患者的经济状况,以确保有效管理 T2DM。利用经常就诊的医生可能会改善 T2DM 的管理,特别是对收入较低的患者。