Department of Gynecology and Obstetrics, Faculty of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG, Brazil.
PLoS One. 2019 Mar 6;14(3):e0212763. doi: 10.1371/journal.pone.0212763. eCollection 2019.
The objective of this study was to analyze the relationships of osmotic and mechanical stability of erythrocytes with anthropometric, biochemical, hematologic and hemodynamic variables in pregnant women with preeclampsia (PE). The studied population consisted of 20 normotensive patients and 16 patients with PE. Patients with PE presented worse gestational outcome, greater hematologic impairment, erythrocytes osmotically more stable in vitro, but in conditions of isotonicity with the in vivo medium, in addition to hyperflow in orbital territory, when compared to normotensive patients. The correlation analysis between anthropometric, hematologic and hemodynamic variables in patients with PE indicated that erythrocytes with lower volumes and lower levels of hemoglobin favor the occurrence of a better gestational outcome, because they are more stable and because they are associated with a decrease in the hemodynamic changes present in the disease. This should mean that the tendency to microcytosis, probably due to a mechanism of compensatory mechanical selection, is a desirable characteristic in the disease.
本研究旨在分析子痫前期（PE）孕妇红细胞渗透和机械稳定性与人体测量学、生化、血液学和血液动力学变量之间的关系。研究人群包括 20 名血压正常的患者和 16 名 PE 患者。与血压正常的患者相比，PE 患者的妊娠结局更差，血液学损伤更大，体外红细胞渗透稳定性更高，但在与体内介质等渗的情况下，眼眶区域的血流量更高。PE 患者的人体测量学、血液学和血液动力学变量之间的相关性分析表明，体积较小、血红蛋白水平较低的红细胞有利于更好的妊娠结局，因为它们更稳定，并且与疾病中存在的血液动力学变化减少有关。这意味着微细胞症的趋势，可能是由于一种机械选择的补偿机制，在这种疾病中是一种理想的特征。
