Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Fitoterapia. 2019 Apr;134:270-289. doi: 10.1016/j.fitote.2019.02.033. Epub 2019 Mar 3.
Diabetes mellitus (DM), a chronic metabolic disease, severely affects patients' life and intensively increases risks of developing other diseases. It is estimated that 0.4 billion individuals worldwide are subjected to diabetes, especially type 2 diabetes mellitus. At present, although various synthetic drugs for diabetes such as Alogliptin and Rosiglitazone, etc. have been used to manage diabetes, some of them showed severe side effects. Given that the pathogenesis of type 2 diabetes mellitus, natural occurring drugs are beneficial alternatives for diabetes therapy with low adverse effects or toxicity. Recently, more and more plant-derived extracts or compounds were evaluated to have anti-diabetic activities. Their anti-diabetic mechanisms involve certain key targets like α-glucosidase, α-amylase, DPP-4, PPAR γ, PTP1B, and GLUT4, etc. Here, we summarize the newly found anti-diabetic (type 2 diabetes mellitus) natural compounds and extracts from 2011-2017, and give the identification of their molecular targets. This review could provide references for the research of natural agents curing type 2 diabetes mellitus (T2DM).
糖尿病（DM）是一种慢性代谢疾病，严重影响患者的生活，并极大地增加了其他疾病的发病风险。据估计，全世界有 0.4 亿人患有糖尿病，其中 2 型糖尿病尤为常见。目前，尽管已经有各种用于治疗糖尿病的合成药物，如阿格列汀和罗格列酮等，但其中一些药物表现出严重的副作用。鉴于 2 型糖尿病的发病机制，天然药物是治疗糖尿病的有益替代物，具有低副作用或低毒性。最近，越来越多的植物提取物或化合物被评估具有抗糖尿病活性。它们的抗糖尿病机制涉及某些关键靶点，如α-葡萄糖苷酶、α-淀粉酶、DPP-4、PPARγ、PTP1B 和 GLUT4 等。在这里，我们总结了 2011 年至 2017 年新发现的具有抗糖尿病（2 型糖尿病）活性的天然化合物和提取物，并对其分子靶点进行了鉴定。这篇综述为研究天然药物治疗 2 型糖尿病（T2DM）提供了参考。
