Modaffari Paola, Ponzone Riccardo, Ferrari Alberta, Cipullo Isabella, Liberale Viola, D'Alonzo Marta, Maggiorotto Furio, Biglia Nicoletta
Academic Division of Gynaecology and Obstetrics, University of Turin School of Medicine, Largo Turati 62, 10128 Torino, Italy.
Department of Gynaecological Oncology, Candiolo Cancer Institute, 10060 Candiolo, Italy.
J Clin Med. 2019 Mar 5;8(3):313. doi: 10.3390/jcm8030313.
Hereditary Breast and Ovarian Cancer syndrome (HBOC) carriers face complex decisions, which might affect their fertility and body image. Using an anonymous 40-items questionnaire we evaluated the expectations and concerns about Risk-Reducing Surgery (RRS) in 204 carriers. Participants are well-informed about the options to manage cancer risk, and women with previous cancer are more concerned with screening failure. Satisfaction with RR Mastectomy is high, even if many carriers are unsatisfied with reconstructed breast feel and nipple-areola complex tactile sensation and those with previous breast cancer report a change in their sexual habits. The decrease of libido and vaginal dryness are the most complained symptoms after RR Salpingo-Oophorectomy. Nevertheless, most carriers would choose RRS again, due to cancer risk or screening-related stress reduction. Women who deferred RRS are more afraid of menopausal symptoms and cancer risk than those who had undergone or declined surgery. Women who declined RRS feel well-informed and trust screening procedures. In conclusion, HBOC carriers consider themselves well-informed and able to choose the best option for their condition, would choose RRS again because of cancer risk and screening-related stress reduction, and those who delay RRS face a higher preoperative level of concern and need support.
遗传性乳腺癌和卵巢癌综合征（HBOC）携带者面临着复杂的决策，这些决策可能会影响她们的生育能力和身体形象。我们使用一份包含40个条目的匿名问卷，对204名携带者关于降低风险手术（RRS）的期望和担忧进行了评估。参与者对管理癌症风险的选择有充分了解，且曾患癌症的女性更担心筛查失败。对RR乳房切除术的满意度较高，尽管许多携带者对重建乳房的感觉和乳头乳晕复合体的触觉不满意，且曾患乳腺癌的携带者报告其性行为习惯发生了改变。RR输卵管卵巢切除术后，性欲减退和阴道干燥是最常被抱怨的症状。然而，由于癌症风险或与筛查相关的压力减轻，大多数携带者会再次选择RRS。推迟RRS的女性比接受或拒绝手术的女性更害怕更年期症状和癌症风险。拒绝RRS的女性认为自己已充分了解情况并信任筛查程序。总之，HBOC携带者认为自己已充分了解情况并能够为自己的状况选择最佳方案，会因癌症风险和与筛查相关的压力减轻而再次选择RRS，而那些推迟RRS的人术前担忧程度更高，需要支持。
