Eisenberg B M, Frille J, Linss G, Günther K H, Taube C, Strangfeld D, Förster W
Cor Vasa. 1986;28(1):38-43.
The aim of the study was to test whether there are typical changes in haemodynamics and humoral regulation in untreated hypertensives compared to normotensives with acute lowering of blood pressure (and venous return) induced by nitroglycerin (NTG). 23 hypertensives were investigated by radiocardiography and microcatheterization of the pulmonary artery as well as by means of humoral analyses in comparison to 10 normotensives. After performing the studies at rest and during exercise, 0.8 mg NTG was given and the investigations were repeated. There were only insignificant differences in cardiac output and left ventricular filling pressure (PAEDP) at rest and during exercise between both groups. The pressure reductions due to NTG were also similar. Plasma renin activity and plasma kallikrein did not differ in hypertensives and normotensives either at rest and during exercise or after NTG. The prostaglandins (PgE, PgF2-alpha, PgI) were extremely variable. In hypertensives, only PgI was decreased, with increase after NTG, at rest. Thus, PgI is the only humoral indicator participating in blood pressure lowering induced by NTG.
该研究的目的是测试与使用硝酸甘油（NTG）诱导急性降低血压（和静脉回流）的正常血压者相比，未经治疗的高血压患者在血流动力学和体液调节方面是否存在典型变化。与10名正常血压者相比，通过放射性心动图、肺动脉微导管插入术以及体液分析对23名高血压患者进行了研究。在静息和运动状态下进行研究后，给予0.8毫克NTG，并重复进行研究。两组在静息和运动状态下的心输出量和左心室充盈压（PAEDP）仅存在不显著差异。NTG导致的血压降低也相似。高血压患者和正常血压者在静息、运动时或NTG给药后，血浆肾素活性和血浆激肽释放酶均无差异。前列腺素（PgE、PgF2-α、PgI）变化极大。在高血压患者中，仅静息时PgI降低，NTG给药后升高。因此，PgI是参与NTG诱导血压降低的唯一体液指标。
