Salaün J, Calman F, Coltey M, Le Douarin N M
Eur J Immunol. 1986 May;16(5):523-30. doi: 10.1002/eji.1830160511.
Normal thymuses develop in the coelomic cavity of mice following grafts carried out in utero into embryonic day 16 to 17 fetuses of the third branchial arch region removed from 10-day embryos. The recipients were killed at various times (up to 29 days after birth) and the thymic lobes which developed from the graft were recovered. Microscopical examination and immunocytochemistry revealed that these thymuses developed normally whether the grafts involved syngeneic or allogeneic (between BALB/c and C3H) strain combinations. Two major populations of class II-expressing cells could be recognized by the Ia allotype they expressed: epithelial cells of donor type and accessory cells of host origin.
在子宫内将取自10日龄胚胎的第三鳃弓区域移植到胚胎第16至17天的胎儿后，正常胸腺在小鼠的体腔中发育。在不同时间（出生后长达29天）处死受体，并回收从移植物发育而来的胸腺叶。显微镜检查和免疫细胞化学显示，无论移植物涉及同基因还是异基因（BALB/c和C3H之间）品系组合，这些胸腺均正常发育。通过它们表达的Ia同种异型可以识别出两类主要的II类表达细胞：供体类型的上皮细胞和宿主来源的辅助细胞。
