突触体对丙酮酸的利用不依赖于钙。
Pyruvate utilization by synaptosomes is independent of calcium.
作者信息
Kauppinen R A, Nicholls D G
出版信息
FEBS Lett. 1986 Apr 21;199(2):222-6. doi: 10.1016/0014-5793(86)80484-7.
PMID:3084295
Abstract
The significance of Ca2+ is assessed for the activation of pyruvate by intact nerve terminals (synaptosomes). Titration of glucose-depleted synaptosomes with pyruvate in the presence of either veratridine or uncoupler stimulates respiration in a Ca2+-independent manner. Additionally, the ability of exogenous pyruvate to support the mitochondrial membrane potential in situ is independent of Ca2+. It is concluded that Ca2+ does not regulate pyruvate oxidation in intact synaptosomes.
摘要
评估了Ca2+对完整神经末梢（突触体）激活丙酮酸的意义。在藜芦碱或解偶联剂存在的情况下，用丙酮酸滴定葡萄糖耗尽的突触体以一种不依赖Ca2+的方式刺激呼吸。此外，外源性丙酮酸在原位维持线粒体膜电位的能力也不依赖于Ca2+。得出的结论是，Ca2+不调节完整突触体中的丙酮酸氧化。
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