Tseng Yu-Jen, Dong Ling, Liu Yu-Feng, Xu Nuo, Ma Wei, Weng Shu-Qiang, Janssen Harry L A, Wu Sheng-Di
Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shanghai Institute of Liver Diseases, Shanghai, 200032, China.
Curr Protein Pept Sci. 2019;20(8):817-822. doi: 10.2174/1389203720666190305165203.
Autophagy entails the removal of dysfunctional components to maintain cellular homeostasis. Over the years, studies of autophagy demonstrated its complex physiological and pathological roles in the liver. Apart from regulation of normal metabolic functions such as glycogenolysis, glycogenesis, and β-oxidation, autophagy also contributes to the modulation of various liver diseases. In this review, we provide a concise overview of the role of autophagy in regulating hepatic metabolism in healthy conditions and various chronic liver diseases. A well-rounded understanding of the role of autophagy may provide insight for future medical advancements in the field of hepatology.
自噬需要清除功能失调的成分以维持细胞内稳态。多年来，对自噬的研究表明其在肝脏中具有复杂的生理和病理作用。除了调节糖原分解、糖原合成和β氧化等正常代谢功能外，自噬还参与各种肝脏疾病的调节。在本综述中，我们简要概述了自噬在健康状态和各种慢性肝病中调节肝脏代谢的作用。全面了解自噬的作用可能为肝病学领域未来的医学进展提供思路。
