Doelle G C, Evans R M, Alexander A N, Rivier J, Vale W, Rabin D
Horm Metab Res. 1986 Mar;18(3):201-2. doi: 10.1055/s-2007-1012270.
The agonist analogue of gonadotropin-releasing hormone (GnRH), [(imBz1)-D-His6,Pro9-NEt]GnRH, has a potency 200 times that of the native hormone in vitro. In single dose studies in man, this analogue resulted in 2- to 4-fold elevation of LH and FSH, and demonstrated a prolonged duration of activity. [(imBz1)-D-His6,Pro9-NEt]GnRH appears to be safe and, as with other analogues of GnRH, may have application to clinical medicine.
促性腺激素释放激素（GnRH）的激动剂类似物[(imBz1)-D-His6,Pro9-NEt]GnRH在体外的效力是天然激素的200倍。在人体单剂量研究中，该类似物使促黄体生成素（LH）和促卵泡生成素（FSH）升高了2至4倍，并显示出延长的活性持续时间。[(imBz1)-D-His6,Pro9-NEt]GnRH似乎是安全的，并且与GnRH的其他类似物一样，可能在临床医学中有应用。
