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Reply: PART and amyloid cascade hypotheses are alive and well (but are not so simple).
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Long-term Dietary Fat Intervention Affects Retinal Health in APOE Mice.
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SUDEP risk is influenced by longevity genomics: a polygenic risk score study.
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Advances in Genetic Risk Scores for Alzheimer's Disease and Dementia: A Systematic Review.
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High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed dementia cohort.
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APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases.
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APOE ε4 Carriage is Associated with Hippocampus-Olfactory Tract Functional Connectivity.
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Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight.
Nat Rev Immunol. 2018 Dec;18(12):759-772. doi: 10.1038/s41577-018-0051-1.
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Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study.
Lancet Neurol. 2018 Sep;17(9):773-781. doi: 10.1016/S1474-4422(18)30251-5. Epub 2018 Aug 6.
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Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis.
N Engl J Med. 2018 Jul 5;379(1):22-31. doi: 10.1056/NEJMoa1716793.
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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis.
N Engl J Med. 2018 Jul 5;379(1):11-21. doi: 10.1056/NEJMoa1716153.
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Racial/ethnic variation of alleles for lobar intracerebral hemorrhage.
Neurology. 2018 Jul 31;91(5):e410-e420. doi: 10.1212/WNL.0000000000005908. Epub 2018 Jun 29.
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Review and meta-analysis of genetic polymorphisms associated with exceptional human longevity.
Mech Ageing Dev. 2018 Oct;175:24-34. doi: 10.1016/j.mad.2018.06.002. Epub 2018 Jun 8.
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Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated.
Brain. 2018 Jul 1;141(7):2181-2193. doi: 10.1093/brain/awy146.
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APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron. 2018 Jun 27;98(6):1141-1154.e7. doi: 10.1016/j.neuron.2018.05.008. Epub 2018 May 31.
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Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau.
JAMA Neurol. 2018 Aug 1;75(8):989-998. doi: 10.1001/jamaneurol.2018.0821.
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GWAS on family history of Alzheimer's disease.
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