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Reply: PART and amyloid cascade hypotheses are alive and well (but are not so simple).

作者信息

Braak Heiko, Del Tredici Kelly

机构信息

Clinical Neuroanatomy, Department of Neurology, Center for Biomedical Research, University of Ulm, Helmholtzstraße 8/1, 89081, Ulm, Germany.

出版信息

Acta Neuropathol. 2025 Aug 6;150(1):15. doi: 10.1007/s00401-025-02921-3.

DOI:10.1007/s00401-025-02921-3
PMID:40767959
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12328507/
Abstract
摘要

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本文引用的文献

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PART and amyloid cascade hypotheses are alive and well (but are not so simple). Scientific commentary on: "Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-beta deposits".淀粉样蛋白瀑布假说依然活跃且合理(但并非如此简单)。关于“无β淀粉样蛋白沉积病例海马结构中早期阿尔茨海默病相关tau包涵体的序列和轨迹”的科学评论。
Acta Neuropathol. 2025 Aug 6;150(1):14. doi: 10.1007/s00401-025-02920-4.
2
Sequence and trajectory of early Alzheimer's disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits.无淀粉样β沉积病例海马结构中早期阿尔茨海默病相关tau包涵体的序列和轨迹
Acta Neuropathol. 2025 May 23;149(1):50. doi: 10.1007/s00401-025-02862-x.
3
LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP.晚期神经认知障碍3期:一种区分重度晚期神经认知障碍与额颞叶痴呆-4型的诊断标准。
Acta Neuropathol. 2025 Apr 28;149(1):38. doi: 10.1007/s00401-025-02876-5.
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The neuropathologic basis for translational biomarker development in the macaque model of late-onset Alzheimer's disease.迟发性阿尔茨海默病猕猴模型中转化生物标志物开发的神经病理学基础。
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