Garlapati Chakravarthy, Joshi Shriya, Sahoo Bikram, Kapoor Shobhna, Aneja Ritu
Department of Biology, Georgia State University, Atlanta, GA, USA.
Department of Chemistry, Indian Institute of Technology Bombay, Powai, India.
Front Biosci (Schol Ed). 2019 Mar 1;11(1):75-88. doi: 10.2741/S527.
Triple-negative breast cancer (TNBC) is characterized by the absence of estrogen and progesterone receptors and absence of amplification of human epidermal growth factor receptor (HER2). This disease has no approved treatment with a poor prognosis particularly in African-American (AA) as compared to European-American (EA) patients. Gene ontology analysis showed specific gene pathways that are differentially regulated and gene signatures that are differentially expressed in AA as compared to EA. Such differences might underlie the basis for the aggressive nature and poor prognosis of TNBC in AA patients. In-depth studies of these pathways and differential genetic signature might give significant clues to improve our understanding of tumor biology associated with AA TNBC to advance the prognosis and survival rates. Along with gene ontology analysis, we suggest that post-translational modifications (PTM) could also play a crucial role in the dismal survival rate of AA TNBC patients. Further investigations are necessary to explore this terrain of PTMs to identify the racially disparate burden in TNBC.
三阴性乳腺癌（TNBC）的特征是缺乏雌激素和孕激素受体，且人表皮生长因子受体（HER2）无扩增。这种疾病尚无获批的治疗方法，预后较差，尤其是与欧美（EA）患者相比，非裔美国（AA）患者的预后更差。基因本体分析显示，与EA相比，AA中存在差异调节的特定基因通路和差异表达的基因特征。这些差异可能是AA患者TNBC具有侵袭性和预后不良的基础。对这些通路和差异基因特征进行深入研究，可能会为增进我们对与AA TNBC相关的肿瘤生物学的理解、改善预后和生存率提供重要线索。除了基因本体分析，我们认为翻译后修饰（PTM）在AA TNBC患者的低生存率中也可能起关键作用。有必要进一步研究PTM领域，以确定TNBC中种族差异负担。
