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转移性神经内分泌癌表现为多灶性肝病变伴甲胎蛋白升高。

Metastatic neuroendocrine carcinoma presenting as multifocal liver lesions with elevated alpha-fetoprotein.

作者信息

Sobotka Lindsay A, Hake Timothy, Kelly Crystal, Mousa Luay

机构信息

Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus Ohio.

Department of Hematology The Ohio State Wexner Medical Center Columbus Ohio.

出版信息

Clin Case Rep. 2018 Dec 16;7(2):251-253. doi: 10.1002/ccr3.1956. eCollection 2019 Feb.

DOI:10.1002/ccr3.1956
PMID:30847183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6389483/
Abstract

Significant elevations in alpha-fetoprotein should raise suspicion for hepatocellular carcinoma as malignancies with metastasis to the liver can elevate the alpha-fetoprotein level but typically <300 ng/mL. Diagnosis should be confirmed with typical characteristics of hepatocellular carcinoma on imaging and or liver biopsy to confirm diagnosis.

摘要

甲胎蛋白显著升高应引起对肝细胞癌的怀疑，因为转移至肝脏的恶性肿瘤可使甲胎蛋白水平升高，但通常<300 ng/mL。诊断应通过影像学上肝细胞癌的典型特征和/或肝活检来确诊。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b56f/6389483/099feb783532/CCR3-7-251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b56f/6389483/8e2b4ff17e79/CCR3-7-251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b56f/6389483/099feb783532/CCR3-7-251-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b56f/6389483/8e2b4ff17e79/CCR3-7-251-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b56f/6389483/099feb783532/CCR3-7-251-g002.jpg

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Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States.美国神经内分泌肿瘤患者的发病率、患病率和生存结局趋势。
JAMA Oncol. 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589.
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Elevated serum alpha-fetoprotein in poorly differentiated adenocarcinoma with neuroendocrine differentiation of the ascending colon: a case report.
升结肠低分化腺癌伴神经内分泌分化患者血清甲胎蛋白升高：病例报告
World J Surg Oncol. 2016 Mar 15;14:84. doi: 10.1186/s12957-016-0838-0.
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BMC Gastroenterol. 2015 Feb 12;15:16. doi: 10.1186/s12876-015-0246-x.
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World J Surg Oncol. 2014 Dec 29;12:400. doi: 10.1186/1477-7819-12-400.
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Cancer. 2015 Feb 15;121(4):589-97. doi: 10.1002/cncr.29099. Epub 2014 Oct 13.
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