Jaber Louay, Fatani Hanadi, Aldhahri Saleh F
College of Dentistry Imam Abdulrahman Bin Faisal University Saudi Arabia.
Department of Pathology King Fahad Medical City Saudi Arabia.
Clin Exp Dent Res. 2019 Jan 29;5(1):38-43. doi: 10.1002/cre2.153. eCollection 2019 Feb.
This study aimed to examine the possible association of human papillomavirus (HPV) with oral cavity squamous cell carcinomas (OCSCCs) in Saudi Arabia. Forty-five paraffin-embedded tumor blocks that represent different subsets of OCSCCs between 2010 and 2014 were retrieved and histologically evaluated. The presence of high-risk HPV (16, 18, 31, and 33) was assessed by p16-immunohistochemistry followed by DNA detection using in situ hybridization technique. Twenty-four patients were male with the mean age of 59.3 years, and 21 patients were female with the mean age of 61.2 years. Forty-one cases were positive for p16 immunostaining, and the remaining four cases were negative. However, none of the 45 cases showed DNA-expression for any HPV subtypes (16, 18, 31, and 33). High-risk HPV appears not to be involved in the etiology of OCSCCs in older Saudi patients, but further studies with cross section of a younger age group are still required.
本研究旨在探讨沙特阿拉伯人乳头瘤病毒（HPV）与口腔鳞状细胞癌（OCSCC）之间可能存在的关联。检索了2010年至2014年间代表OCSCC不同亚组的45个石蜡包埋肿瘤块，并进行了组织学评估。通过p16免疫组织化学评估高危型HPV（16、18、31和33型）的存在情况，随后使用原位杂交技术进行DNA检测。24例患者为男性，平均年龄59.3岁，21例患者为女性，平均年龄61.2岁。41例p16免疫染色呈阳性，其余4例为阴性。然而，45例病例中无一例显示任何HPV亚型（16、18、31和33型）的DNA表达。高危型HPV似乎未参与沙特老年患者OCSCC的病因，但仍需要对更年轻年龄组进行进一步的横断面研究。
