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赫尔曼(休)·布拉施科(1900 - 1993):他对生化药理学和临床医学的重要贡献。

Hermann (Hugh) Blaschko (1900-1993): His fundamental contributions to biochemical pharmacology and clinical medicine.

作者信息

Rubin Ronald P

机构信息

Department of Pharmacology & Toxicology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.

出版信息

J Med Biogr. 2019 Aug;27(3):179-183. doi: 10.1177/0967772017703091. Epub 2019 Mar 8.

Abstract

Hermann (Hugh) Blaschko was a biochemical pharmacologist best known for discovering how adrenaline (epinephrine), noradrenaline (norepinephrine), and dopamine were synthesized, stored, and metabolized in adrenomedullary cells and sympathetic nerves. Blaschko's work not only supported the validity of the concept of neurochemical synaptic transmission but he also made fundamental contributions to the development of drugs used in clinical medicine to treat diseases such as depression, hypertension, and Parkinson's Disease.

摘要

赫尔曼(休)·布拉施科是一位生化药理学家,他最为人所知的是发现了肾上腺素、去甲肾上腺素和多巴胺在肾上腺髓质细胞和交感神经中是如何合成、储存和代谢的。布拉施科的工作不仅支持了神经化学突触传递概念的有效性,还为临床医学中用于治疗抑郁症、高血压和帕金森病等疾病的药物开发做出了重要贡献。

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