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Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Associated with Ethambutol use: A Case Report.

作者信息

Kapur Ajita, Rehan Harmeet Singh

机构信息

Department of Pharmacology, Lady Hardinge Medical College and Associated Hospitals, New Delhi 110001, India.

出版信息

Curr Drug Saf. 2019;14(3):249-251. doi: 10.2174/1574886314666190307150757.

DOI:10.2174/1574886314666190307150757
PMID:30848209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6864591/
Abstract

BACKGROUND

Among the first line Anti-Tubercular Drugs (ATDs), ethambutol has been rarely associated to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

CASE REPORT

A 34-year-old woman presented in an out-patient department of Dermatology with fever, skin eruptions, eosino- philia, hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs. The patient recovered completely after stopping ethambutol and administration of topical and sys- temic corticosteroids.

RESULTS AND CONCLUSION

Based on the available evidences of de-challenge and re-challenge of suspected drugs, ethambutol was certainly implicated to cause DRESS syndrome.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d3/6864591/591d6329042c/CDS-14-249_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d3/6864591/591d6329042c/CDS-14-249_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d9d3/6864591/591d6329042c/CDS-14-249_F1.jpg

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本文引用的文献

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Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome due to ethambutol.由乙胺丁醇引起的伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征。
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Antituberculosis Drug-Associated DRESS: A Case Series.
抗结核药物相关性 DRESS：病例系列。
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