Jentzsch Madlen, Schwind Sebastian, Vucinic Vladan, Wendt Sebastian, Stingu Catalina-Suzana, Niederwieser Dietger, Weidhase Lorenz
Medizinische Klinik und Poliklinik I - Hämatologie und Zelltherapie, Internistische Onkologie, Hämostaseologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Institut für Mikrobiologie und Infektionsepidemiologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Med Klin Intensivmed Notfmed. 2020 May;115(4):340-342. doi: 10.1007/s00063-019-0552-0. Epub 2019 Mar 8.
Infections with Neisseriameningitidis are life-threatening conditions, generally presenting as meningitis. This case of a young woman who had a history of paroxysmal nocturnal hemoglobinuria under treatment with the complement inhibitor eculizumab had been presented with septic shock. While blood cultures were positive for Neisseria meningitidis, she showed no evidence for bacterial meningitis in the cerebrospinal fluid. This case shows that meningococcal sepsis without signs for bacterial meningitis despite repetitive vaccinations is possible in adults under eculizumab.
感染脑膜炎奈瑟菌会危及生命，通常表现为脑膜炎。该病例为一名年轻女性，既往有阵发性夜间血红蛋白尿病史，正在接受补体抑制剂依库珠单抗治疗，此次出现感染性休克。虽然血培养显示脑膜炎奈瑟菌阳性，但脑脊液检查未发现细菌性脑膜炎的证据。该病例表明，在接受依库珠单抗治疗的成年人中，尽管反复接种疫苗，仍有可能发生无细菌性脑膜炎体征的脑膜炎球菌败血症。
