Ciuca Cristina, Ragni Luca, Hasan Tammam, Balducci Anna, Angeli Emanuela, Prandstraller Daniela, Egidy-Assenza Gabriele, Donti Andrea, Bonvicini Marco, Gargiulo Gaetano D
Pediatric Cardiology & GUCH Unit, Cardiothoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Bologna, 40138, Italy.
Pediatric & Grown-up Congenital Cardiac Surgery Unit, Cardiothoracic-Vascular Department, University Hospital S. Orsola-Malpighi, Bologna, 40138, Italy.
Future Cardiol. 2019 Mar;15(2):95-107. doi: 10.2217/fca-2018-0030. Epub 2019 Mar 8.
The aim of the study was to assess predictors of outcome in patients hospitalized for dilated cardiomyopathy (DCM) and severe left ventricular dysfunction. Patients & methods: 83 pediatric patients hospitalized for heart failure due to DCM with coexistent left ventricular dysfunction were enrolled.
Overall, 5-year survival free from heart transplantation was 69.8%. Normalization of left ventricular function was achieved in 39.8% of patients during follow-up: younger age, less necessity of inotropic support and other than idiopathic DCM predicted left ventricular function, while familial history for cardiac disease or sudden death and inotropic support during hospitalization were associated with poorer outcome.
Almost 40% of patients with DCM experienced a complete normalization of cardiac function. Outcome was extremely variable according to the type of DCM.
本研究旨在评估因扩张型心肌病（DCM）和严重左心室功能不全住院患者的预后预测因素。患者与方法：纳入83例因DCM合并左心室功能不全而住院治疗心力衰竭的儿科患者。
总体而言，无心脏移植的5年生存率为69.8%。随访期间39.8%的患者左心室功能恢复正常：年龄较小、较少需要使用正性肌力药物支持以及非特发性DCM可预测左心室功能，而心脏病家族史或猝死家族史以及住院期间使用正性肌力药物支持与较差的预后相关。
近40%的DCM患者心脏功能完全恢复正常。根据DCM的类型，预后差异极大。
