Welch J S
Mayo Clin Proc. 1986 May;61(5):392-5. doi: 10.1016/s0025-6196(12)61960-0.
High-energy irradiation is used increasingly as a part of breast conservation treatment of malignant disease. The response of the breast tissue encompassed by the treatment fields varies considerably, even in well-conducted therapeutic programs. Early and late changes in the tissues include redness, edema, pigmentation, fibrosis, and retraction. Fibrosis and retraction may cause suboptimal cosmetic results and occur most frequently in obese patients, large breasts, and breasts from which a large (greater than 4 cm) primary tumor has been excised. Combinations of treatment modalities, such as adjuvant chemotherapy, surgical excision, and irradiation, seem to produce fewer excellent cosmetic results than single-modality treatment. In patients who have undergone breast conservation treatment, careful follow-up is necessary for detection of possible local, regional, or distant recurrence of the malignant disease, as well as of other diseases related or unrelated to the earlier treatment.
高能辐射越来越多地被用作恶性疾病保乳治疗的一部分。即使在实施良好的治疗方案中，治疗区域内乳房组织的反应也有很大差异。组织的早期和晚期变化包括发红、水肿、色素沉着、纤维化和回缩。纤维化和回缩可能导致不理想的美容效果，最常发生在肥胖患者、乳房较大的患者以及已切除大（大于4厘米）原发性肿瘤的乳房患者中。辅助化疗、手术切除和放疗等治疗方式的组合似乎比单一治疗方式产生的理想美容效果更少。在接受过保乳治疗的患者中，需要仔细随访，以检测恶性疾病可能的局部、区域或远处复发，以及与早期治疗相关或无关的其他疾病。
