Millis R M, Wood D H, Trouth C O
Life Sci. 1986 May 12;38(19):1767-74. doi: 10.1016/0024-3205(86)90127-x.
We studied anesthetized dogs subjected to graded increases in intracranial pressure (ICP) to assess the role of the systemic vasopressor (Cushing) response in the arterial hypoxemia associated with increased ICP. The arterial PO2 decrement was significantly greater with rapidly increased ICP compared to slowly increased ICP (P less than 0.01). Systemic vasopressor responses generated in cats by direct electrical stimulation of the vasomotor center resulted in arterial hypoxemia during controlled ventilation. Therefore, arterial hypoxemia was coincident with increased systemic blood pressure produced by either elevation of ICP or electrical stimulation of the vasomotor center.
我们研究了颅内压（ICP）逐步升高的麻醉犬，以评估全身性血管升压（库欣）反应在与ICP升高相关的动脉低氧血症中的作用。与ICP缓慢升高相比，ICP快速升高时动脉血氧分压（PO2）的下降明显更大（P<0.01）。通过直接电刺激猫的血管运动中枢产生的全身性血管升压反应在控制通气期间导致动脉低氧血症。因此，动脉低氧血症与由ICP升高或电刺激血管运动中枢所产生的全身血压升高同时出现。
