Department of Psychiatry, Hospital General Universitario de Elche , Alicante , Spain.
Int J Psychiatry Clin Pract. 2019 Sep;23(3):189-193. doi: 10.1080/13651501.2019.1576905. Epub 2019 Mar 8.
Hyperprolactinemia (HPRL), defined as plasma prolactin (PRL) >25 ng/ml, is a frequent adverse effect of the treatment with some antipsychotics. The objectives of this study were to determine the prevalence of HPRL among schizophrenic patients treated with long-acting injectable (LAI) antipsychotic drugs at our hospital, and to estimate gender effects in PRL levels in these patients. This cross-sectional, retrospective, study analyzed 165 psychotic patients treatment with LAI antipsychotics in monotherapy from February to May of 2017 at the Psychiatry Specialized Care Units of the Elche General Hospital (Spain). The prevalence of antipsychotic-derived HPRL in our hospital was 52.41%. Patients treated with LAI formulations of paliperidone and risperidone presented the highest levels of HPRL. A linear regression model showed that female patients presented 24.95 ng/ml (CI95 = 16.85, 33.05) higher levels of PRL than male patients ( < .0001). For women, age >45 years was associated to reduced levels of PRL with respect to younger patients (mean= -18.86 ng/ml, CI95 = -35.59, -2.13, < .05). Our study confirmed the effects of LAI paliperidone and risperidone on PRL levels. Sex and age were significantly associated with PRL levels in patients treated with LAI antipsychotics, with younger women presenting higher rates of HPRL than men. Key points HPRL is a common adverse effect of the treatment with antipsychotics, detectable in over half of the patients treated in our hospital. Our study showed that treatment with LAI formulations of paliperidone and risperidone resulted in the highest levels of HPRL. Sex and age were significantly associated with PRL levels in patients treated with LAI antipsychotic drugs, with younger women presenting higher rates of HPRL than men.
高泌乳素血症（HPRL）定义为血浆泌乳素（PRL）>25ng/ml，是一些抗精神病药物治疗的常见不良反应。本研究的目的是确定我院接受长效注射（LAI）抗精神病药物治疗的精神分裂症患者中 HPRL 的患病率，并估计这些患者 PRL 水平的性别影响。这项横断面、回顾性研究分析了 2017 年 2 月至 5 月在西班牙埃尔切综合医院精神病学专科护理病房接受 LAI 抗精神病药物单一治疗的 165 例精神病患者。我院抗精神病药物引起的 HPRL 患病率为 52.41%。接受棕榈酸帕利哌酮和利培酮 LAI 制剂治疗的患者出现 HPRL 的水平最高。线性回归模型显示，女性患者的 PRL 水平比男性患者高 24.95ng/ml（CI95=16.85，33.05）（ < .0001）。对于女性，年龄>45 岁与年轻患者相比，PRL 水平降低（平均=-18.86ng/ml，CI95=-35.59，-2.13， < .05）。本研究证实了 LAI 棕榈酸帕利哌酮和利培酮对 PRL 水平的影响。性别和年龄与接受 LAI 抗精神病药物治疗的患者的 PRL 水平显著相关，年轻女性比男性发生 HPRL 的比例更高。关键点 HPRL 是抗精神病药物治疗的常见不良反应，在我院接受治疗的患者中超过一半可检测到。我们的研究表明，接受棕榈酸帕利哌酮和利培酮 LAI 制剂治疗的患者 HPRL 发生率最高。性别和年龄与接受 LAI 抗精神病药物治疗的患者的 PRL 水平显著相关，年轻女性比男性发生 HPRL 的比例更高。
