二十碳五烯酸可改善顺铂诱导的肌肉萎缩而不伴体重增加。
Eicosapentaenoic Acid Improves Cisplatin-Induced Muscle Atrophy Without Accompanying Body Weight Gain.
机构信息
a Laboratory of Pharmacology and Therapeutics Faculty of Pharmaceutical Sciences , Tokyo University of Science , Tokyo , Japan.
b Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery , Nippon Medical School , Tokyo , Japan.
出版信息
Nutr Cancer. 2019;71(3):439-443. doi: 10.1080/01635581.2019.1578386. Epub 2019 Mar 8.
INTRODUCTION
Cisplatin (CDDP) induces loss of muscle mass by activating the nuclear factor (NF)-κB signaling pathway. In this study, we investigated the effects of eicosapentaenoic acid (EPA), which inhibits NF-κB activation, on CDDP-induced loss of muscle mass in mice.
METHODS
Male C57BL/6J mice received a single dose of CDDP and olive oil, linseed oil, or EPA daily for 4 days. Body weight and food intake were recorded daily for 5 days. Forelimb grip strength was determined using a strain gauge on the fourth day. The mice were killed 24 h after the final dose of fatty acid and the wet weight of their gastrocnemius, soleus, and tibialis anterior muscles measured.
RESULTS
Olive oil, linseed oil, and EPA all failed to prevent decrease in food intake and loss of body weight. However, only EPA prevented loss of muscle mass and strength.
CONCLUSION
EPA prevents CDDP-related loss of muscle mass and muscle but not CDDP-related loss of body weight.
简介
顺铂（CDDP）通过激活核因子（NF）-κB 信号通路导致肌肉质量下降。在这项研究中，我们研究了二十碳五烯酸（EPA）的作用，EPA 能抑制 NF-κB 的激活，从而研究 EPA 对 CDDP 诱导的小鼠肌肉质量下降的影响。
方法
雄性 C57BL/6J 小鼠接受单次 CDDP 和橄榄油、亚麻籽油或 EPA 处理，每天一次，共 4 天。连续 5 天记录体重和食物摄入量。在第四天使用应变计测定前肢握力。在最后一次脂肪酸给药后 24 小时处死小鼠，测量其比目鱼肌、腓肠肌和胫骨前肌的湿重。
结果
橄榄油、亚麻籽油和 EPA 均不能预防食物摄入量减少和体重减轻。然而，只有 EPA 能防止肌肉质量和力量的丧失。
结论
EPA 可预防 CDDP 相关的肌肉质量和肌肉损失，但不能预防 CDDP 相关的体重减轻。
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