Regeneration in Hematopoiesis, Leibniz-Institute on Aging-Fritz-Lipmann-Institute (FLI), Beutenbergstrasse 11, 07745 Jena, Germany; Faculty of Biological Sciences, Friedrich-Schiller-University Jena, 07737 Jena, Germany; Department of Medicine III, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
Cell Stem Cell. 2019 Mar 7;24(3):349-350. doi: 10.1016/j.stem.2019.02.014.
Evidence suggests that hematopoietic progenitor cells self-replenish in situ over prolonged time frames, centering the question on the identity and source of growth factors maintaining HPC fidelity. In this issue of Cell Stem Cell, Comazzetto et al. (2019) suggest that normal stem and progenitor function relies on stem cell factor provided by distinct cellular sources.
有证据表明，造血祖细胞在长时间内自我补充，这使得人们关注维持 HPC 保真度的生长因子的身份和来源。在本期《Cell Stem Cell》杂志上，Comazzetto 等人（2019 年）提出，正常的干细胞和祖细胞功能依赖于由不同细胞来源提供的干细胞因子。
