Medical Device Division, R & D Headquarters, Daicel Corporation, Minato-ku, Tokyo, Japan.
Corporate Research Center, Daicel Corporation, Himeji, Hyogo, Japan.
J Pharm Sci. 2019 Jul;108(7):2415-2420. doi: 10.1016/j.xphs.2019.02.021. Epub 2019 Mar 5.
Various jet injectors have been developed and used for the effective and efficient administration of drugs. Jet injections overcome the limitations of other drug delivery methods, such as ablation, iontophoresis, electroporation, sonophoresis, and microneedles, because jet injection is not limited by the diffusion rates of different drugs. However, controlling the jet pressure during drug delivery is difficult with most conventional jet injectors. Efficacy evaluation of such devices on laboratory animals is strongly required before initiating human clinical trials, but minimal research has been performed for the device developments. Therefore, we developed jet injector devices based on pyrotechnics using 2 types of explosives with different burning rates; we call these pyro-drive jet injectors. The liquid jet pressure profile suggests that the penetration depth and injection volume for soft materials and skin tissue are controllable. Here, we propose the pyro-drive jet injectors as another candidate well-controlled jet injector for laboratory animals in drug discovery testing as well as human clinical use.
各种射流注射器已经被开发并用于有效和高效地管理药物。射流注射克服了其他药物输送方法的局限性，如消融、离子电渗、电穿孔、声流和微针，因为射流注射不受不同药物扩散率的限制。然而，大多数传统的射流注射器在药物输送过程中很难控制射流压力。在开始人体临床试验之前，强烈需要对这些设备在实验室动物身上的疗效进行评估，但对于设备开发，研究很少。因此，我们使用两种燃烧速度不同的炸药开发了基于烟火技术的射流注射器；我们称之为 pyro-drive 射流注射器。液体射流压力曲线表明，软材料和皮肤组织的穿透深度和注射量是可控的。在这里，我们提出 pyro-drive 射流注射器作为另一种候选可控射流注射器，用于药物发现测试中的实验室动物以及人类临床使用。
