Steinberger Jeremy, Nistal Dominic A, Ghatan Saadi
J Neurosurg Pediatr. 2019 Mar 8;23(6):694-698. doi: 10.3171/2018.12.PEDS18554. Print 2019 Jun 1.
Infantile hemangiomas (IHs) are the most common benign neoplasm of the neonatal and newborn period, affecting approximately 5% of infants. However, true IHs presenting in the neuraxis are quite rare with only 15 documented cases in the literature. Management of IH consists of utilizing steroids and immunomodulatory therapies to reduce the size of the tumor and surgery to remove the tumor to decrease symptoms and the risk of bleeding. Operative management of epidural and intradural extramedullary spinal hemangiomas has been described; however, management of intradural intramedullary IH has not been detailed in the literature. In this report, the authors describe the case of a 3-year-old girl who presented with multiple hemangiomas involving the liver, lung, and spine, with one component of the tumor involving the posterior intramedullary aspect of the spinal cord at the level of T3. After medical therapies had failed, the patient underwent endovascular embolization of the spinal hemangioma followed by resection of the tumor. While there is extensive literature on IH throughout many organ systems, only a handful of cases involving the neuraxis have been described. Operative management of refractory IH seems to allow for the reduction of tumor burden and the prevention of hemorrhagic injury.
婴儿血管瘤(IHs)是新生儿期最常见的良性肿瘤,约5%的婴儿受其影响。然而,真正出现在神经轴的婴儿血管瘤相当罕见,文献中仅有15例记录。婴儿血管瘤的治疗包括使用类固醇和免疫调节疗法来缩小肿瘤大小,以及通过手术切除肿瘤以减轻症状和出血风险。硬膜外和硬膜内髓外脊柱血管瘤的手术治疗已有描述;然而,硬膜内髓内婴儿血管瘤的治疗在文献中尚未详细阐述。在本报告中,作者描述了一名3岁女孩的病例,该女孩患有累及肝脏、肺部和脊柱的多发性血管瘤,其中一个肿瘤成分累及T3水平脊髓的后髓内部分。在药物治疗失败后,患者接受了脊柱血管瘤的血管内栓塞,随后切除了肿瘤。虽然关于婴儿血管瘤在许多器官系统中的文献很多,但仅有少数涉及神经轴的病例被描述。难治性婴儿血管瘤的手术治疗似乎有助于减轻肿瘤负担并预防出血性损伤。